Topologically-based parameter interference for agent-based model selection from spatiotemporal cellular data
AR Wenzel, PM Haughey, KC Nguyen, JT Nardini, JM Haugh, KB Flores
bioRxiv, 2025.06. 13.659586 2025 |
CD44 and Ezrin restrict EGF receptor mobility to generate a novel spatial arrangement of cytoskeletal signaling modules driving bleb–based migration
A Jha, A Chandra, P Farahani, JE Toettcher, JM Haugh, CM Waterman
bioRxiv, 2024.12. 31.630838 2025 |
Quantifying collective motion patterns in mesenchymal cell populations using topological data analysis and agent-based modeling
KC Nguyen, CD Jameson, SA Baldwin, JT Nardini, RC Smith, JM Haugh, KB Flores, Mathematical Biosciences 370, 109158 2024 |
Dissection of MKK6 and p38 Signaling Using Light-Activated Protein Kinases
SMT Rahman, W Zhou, A Deiters, JM Haugh, ChemBioChem 25 (1), e202300551 2024 |
G-actin diffusion is insufficient to achieve F-actin assembly in fast-treadmilling protrusions
R Appalabhotla, MT Butler, JE Bear, JM Haugh, Biophysical Journal 122 (18), 3816-3829 2023 |
Semi-autonomous wound invasion via matrix-deposited, haptotactic cues
SA Baldwin, JM Haugh, Journal of Theoretical Biology 568, 111506 2023 |
On the interference of ERK signaling dynamics from protein biosensor measurements
SMT Rahman, JM Haugh, Molecular Biology of the Cell 34 (6), ar60 2023 |
Isoform-specific optical activation of kinase function reveals p38-ERK signaling crosstalk
W Zhou, A Ryan, CP Janosko, KE Shoger, JM Haugh, RA Gottschalk, A Deiters, RSC Chemical Biology 4 (10), 765-773 2023 |
A kinetic model of phospholipase C-y1 linking structure-based insights to dynamics of enzyme autoinhibition and activation
JL Nosbisch, JE Bear, JM Haugh Journal of Biological Chemistry 298 (5) 2022 |
Modeling cell protrusion predicts how myosin II and actin turnover affect adhesion-based signaling
A Chandra, MT Butler, JE Bear, JM Haugh Biophysical Journal 121 (1), 102-118 2022 |
Microfluidic devices fitted with “flowver” paper pumps generate steady, tunable gradients for extended observation of chemotactic cell migration
SA Baldwin, SM Van Bruggen, JM Koelbl, R Appalabhotla, JE Bear, Biomicrofluidics 15 (4), 044101 2021 |
Optical control of MAP kinase kinase 6 (MKK6) reveals that it has divergent roles in pro-apoptotic and anti-proliferative signaling
SMT Rahman, W Zhou, A Deiters, JM Haugh Journal of Biological Chemistry 295 (25), 8494-8504 2020 |
Mechanistic models of PLC/PKC signaling implicate phosphatidic acid as a key amplifier of chemotactic gradient sensing
JL Nosbisch, A Rahman, K Mohan, TC Elston, JE Bear, JM Haugh PLOS Computational Biology 16 (4), e1007708 2020 |
Emergent spatiotemporal dynamics of the actomyosin network in the presence of chemical gradients
CJ Miller, PK LaFosse, SB Asokan, JM Haugh, JE Bear, TC Elston Integrative Biology 11 (6), 280-292 2019 |
Design and evaluation of engineered protein biosensors for live-cell imaging of EGFR phosphorylation
K Tiruthani, A Mischler, S Ahmed, J Mahinthakumar, JM Haugh, BM Rao Science signaling 12 (584), eaap7584 2019 |
Lysophosphatidic acid provokes fibroblast chemotaxis through combinatorial regulation of myosin II
SB Asokan, HE Johnson, J Sondek, MS Shutova, TM Svitkina, JM Haugh, bioRxiv, 355610 2019 |
A Reaction-Diffusion Model Explains Amplification of the PLC/PKC Pathway in Fibroblast Chemotaxis
K Mohan, JL Nosbisch, TC Elston, JE Bear, JM Haugh Biophysical Journal 113 (1), 185-194 2017 |
Kinetic Modeling and Analysis of the Akt/Mechanistic Target of Rapamycin Complex 1 (mTORC1) Signaling Axis Reveals Cooperative, Feedforward Regulation
A Rahman, JM Haugh Journal of Biological Chemistry 292 (7), 2866-2872 2017 |
Are Filopodia Privileged Signaling Structures in Migrating Cells?
HE Johnson, JM Haugh Biophysical Journal 111 (9), 1827-1830 2016 |
Lamellipodia are crucial for haptotactic sensing and response
SJ King, SB Asokan, EM Haynes, SP Zimmerman, JD Rotty, JG Alb, J Cell Sci 129 (12), 2329-2342 2016 |
Systems Cell Biology: An Overview
DA Lauffenburger, JM Haugh, HM Byrne, R Linding Academic Press 2016 |
Quantitative analysis of B-lymphocyte migration directed by CXCL13
X Liu, SB Asokan, JE Bear, JM Haugh Integrative Biology 8 (8), 894-903 2016 |
GMFβ controls branched actin content and lamellipodial retraction in fibroblasts
EM Haynes, SB Asokan, SJ King, HE Johnson, JM Haugh, JE Bear Journal of Cell Biology 209 (6), 803-812 2015 |
Linking morphodynamics and directional persistence of T lymphocyte migration
X Liu, ES Welf, JM Haugh Journal of The Royal Society Interface 12 (106), 20141412 2015 |
Development of a tandem affinity phosphoproteomic method with motif selectivity and its application in analysis of signal transduction networks
LE Herring, KG Grant, K Blackburn, JM Haugh, MB GosheJournal of Chromatography B 988, 166-174 2015 |
F-actin bundles direct the initiation and orientation of lamellipodia through adhesion-based signaling
HE Johnson, SJ King, SB Asokan, JD Rotty, JE Bear, JM Haugh Journal of Cell Biology 208 (4), 443-455 2015 |
Profilin-1 serves as a gatekeeper for actin assembly by Arp2/3-dependent and-independent pathways
JD Rotty, C Wu, EM Haynes, C Suarez, JD Winkelman, HE Johnson, Developmental cell 32 (1), 54-67 2015 |
Mesenchymal chemotaxis requires selective inactivation of myosin II at the leading edge via a non canonical PLCγ/PKC⍺ pathway
SB Asokan, HE Johnson, A Rahman, SJ King, JD Rotty, IP Lebedeva, Developmental cell 31 (6), 747-760 2014 |